登録情報 | データベース: PDB / ID: 2pav |
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タイトル | Ternary complex of Profilin-Actin with the Last Poly-Pro of Human VASP |
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要素 | - Actin, alpha skeletal muscle
- Profilin-1プロフィリン
- Vasodilator-stimulated phosphoprotein血管拡張因子刺激リン酸化タンパク質
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キーワード | STRUCTURAL PROTEIN (タンパク質) / Ternary complex / Profilin (プロフィリン) / Actin (アクチン) / VASP (VASP航空) / Poly-Proline / Loading Poly-Pro Site |
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機能・相同性 | 機能・相同性情報
synapse maturation / modification of postsynaptic actin cytoskeleton / negative regulation of actin filament bundle assembly / adenyl-nucleotide exchange factor activity / profilin binding / positive regulation of actin filament bundle assembly / negative regulation of actin filament polymerization / Signaling by ROBO receptors / Cell-extracellular matrix interactions / regulation of actin filament polymerization ...synapse maturation / modification of postsynaptic actin cytoskeleton / negative regulation of actin filament bundle assembly / adenyl-nucleotide exchange factor activity / profilin binding / positive regulation of actin filament bundle assembly / negative regulation of actin filament polymerization / Signaling by ROBO receptors / Cell-extracellular matrix interactions / regulation of actin filament polymerization / actin polymerization or depolymerization / positive regulation of ATP-dependent activity / PCP/CE pathway / filopodium membrane / proline-rich region binding / positive regulation of ruffle assembly / negative regulation of stress fiber assembly / cytoskeletal motor activator activity / positive regulation of actin filament polymerization / positive regulation of epithelial cell migration / tropomyosin binding / myosin heavy chain binding / mesenchyme migration / troponin I binding / actin filament bundle / filamentous actin / lamellipodium membrane / skeletal muscle thin filament assembly / actin filament bundle assembly / striated muscle thin filament / Generation of second messenger molecules / skeletal muscle myofibril / actin monomer binding / bicellular tight junction / skeletal muscle fiber development / stress fiber / titin binding / phosphatidylinositol-4,5-bisphosphate binding / actin filament polymerization / phosphotyrosine residue binding / filopodium / neural tube closure / RHO GTPases Activate Formins / マイクロフィラメント / 軸索誘導 / 加水分解酵素; 酸無水物に作用; 酸無水物に作用・細胞または細胞小器官の運動に関与 / modulation of chemical synaptic transmission / small GTPase binding / SH3 domain binding / calcium-dependent protein binding / マイクロフィラメント / Platelet degranulation / lamellipodium / cell body / actin binding / 細胞皮質 / actin cytoskeleton organization / protein homotetramerization / blood microparticle / protein stabilization / 細胞骨格 / hydrolase activity / cadherin binding / protein domain specific binding / focal adhesion / glutamatergic synapse / calcium ion binding / positive regulation of gene expression / regulation of transcription by RNA polymerase II / magnesium ion binding / RNA binding / extracellular exosome / ATP binding / 生体膜 / identical protein binding / 細胞核 / 細胞膜 / 細胞質基質 / 細胞質類似検索 - 分子機能 Vasodilator-stimulated phosphoprotein/ENA/VASP-like / Profilin1/2/3, vertebrate / VASP tetramerisation / VASP tetramerisation domain superfamily / VASP tetramerisation domain / : / Profilin conserved site / Profilin signature. / WH1/EVH1 domain / WH1 domain ...Vasodilator-stimulated phosphoprotein/ENA/VASP-like / Profilin1/2/3, vertebrate / VASP tetramerisation / VASP tetramerisation domain superfamily / VASP tetramerisation domain / : / Profilin conserved site / Profilin signature. / WH1/EVH1 domain / WH1 domain / WH1 domain profile. / WASP homology region 1 / プロフィリン / プロフィリン / プロフィリン / Profilin superfamily / Dynein light chain 2a, cytoplasmic / ATPase, substrate binding domain, subdomain 4 / Actin; Chain A, domain 4 / ATPase, nucleotide binding domain / Actins signature 1. / Actin, conserved site / Actins signature 2. / Actin/actin-like conserved site / Actins and actin-related proteins signature. / Β-ラクタマーゼ / アクチン / Actin family / アクチン / ATPase, nucleotide binding domain / Nucleotidyltransferase; domain 5 / PH-like domain superfamily / Alpha-Beta Complex / 2-Layer Sandwich / Alpha Beta類似検索 - ドメイン・相同性 ADENOSINE-5'-TRIPHOSPHATE / Profilin-1 / 血管拡張因子刺激リン酸化タンパク質 / Actin, alpha skeletal muscle類似検索 - 構成要素 |
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生物種 | Homo sapiens (ヒト) Oryctolagus cuniculus (ウサギ) |
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手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 1.8 Å |
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データ登録者 | Ferron, F. / Rebowski, G. / Dominguez, R. |
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引用 | ジャーナル: Embo J. / 年: 2007 タイトル: Structural basis for the recruitment of profilin-actin complexes during filament elongation by Ena/VASP. 著者: Ferron, F. / Rebowski, G. / Lee, S.H. / Dominguez, R. |
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履歴 | 登録 | 2007年3月27日 | 登録サイト: RCSB / 処理サイト: RCSB |
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改定 1.0 | 2007年10月23日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2011年7月13日 | Group: Version format compliance |
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改定 1.2 | 2013年3月6日 | Group: Advisory / Other |
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改定 1.3 | 2023年8月30日 | Group: Data collection / Database references ...Data collection / Database references / Derived calculations / Refinement description カテゴリ: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model / pdbx_struct_conn_angle / struct_conn / struct_conn_type / struct_ref_seq_dif / struct_sheet / struct_site Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession ..._database_2.pdbx_DOI / _database_2.pdbx_database_accession / _pdbx_struct_conn_angle.ptnr1_auth_seq_id / _pdbx_struct_conn_angle.ptnr3_auth_seq_id / _pdbx_struct_conn_angle.value / _struct_conn.conn_type_id / _struct_conn.id / _struct_conn.pdbx_dist_value / _struct_conn.pdbx_leaving_atom_flag / _struct_conn.ptnr1_auth_comp_id / _struct_conn.ptnr1_auth_seq_id / _struct_conn.ptnr1_label_asym_id / _struct_conn.ptnr1_label_atom_id / _struct_conn.ptnr1_label_comp_id / _struct_conn.ptnr1_label_seq_id / _struct_conn.ptnr2_auth_comp_id / _struct_conn.ptnr2_auth_seq_id / _struct_conn.ptnr2_label_asym_id / _struct_conn.ptnr2_label_atom_id / _struct_conn.ptnr2_label_comp_id / _struct_conn.ptnr2_label_seq_id / _struct_conn_type.id / _struct_ref_seq_dif.details / _struct_sheet.number_strands / _struct_site.pdbx_auth_asym_id / _struct_site.pdbx_auth_comp_id / _struct_site.pdbx_auth_seq_id |
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