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TitleHuman polymerase theta helicase positions DNA microhomologies for double-strand break repair
Journal, issue, pagesTo Be Published
Publish dateApr 19, 2024 (structure data deposition date)
AuthorsZerio CJ / Bai Y / Sosa-Alvarado BA / Guzi T / Lander GC
External linksSearch PubMed
MethodsEM (single particle)
Resolution3.3 - 3.6 Å
Structure data

44534

9bh6

EMDB-44534, PDB-9bh6:
Human DNA polymerase theta helicase domain tetramer in the apo form
Method: EM (single particle) / Resolution: 3.3 Å

44535

9bh7

EMDB-44535, PDB-9bh7:
Human DNA polymerase theta helicase domain dimer in the apo form
Method: EM (single particle) / Resolution: 3.5 Å

44536

9bh8

EMDB-44536, PDB-9bh8:
Human DNA polymerase theta helicase domain dimer bound to DNA in the microhomology searching conformation
Method: EM (single particle) / Resolution: 3.6 Å

44537

9bh9

EMDB-44537, PDB-9bh9:
Human DNA polymerase theta helicase domain dimer bound to DNA in the microhomology aligning conformation
Method: EM (single particle) / Resolution: 3.5 Å

44538

9bha

EMDB-44538, PDB-9bha:
Human DNA polymerase theta helicase domain dimer bound to DNA in the microhomology annealed conformation
Method: EM (single particle) / Resolution: 3.5 Å

Source
  • homo sapiens (human)
  • synthetic construct (others)
KeywordsDNA BINDING PROTEIN / DNA repair / TMEJ / MMEJ

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