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- PDB-6weq: DENV1 NS1 in complex with neutralizing 2B7 Fab fragment -

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Basic information

Entry
Database: PDB / ID: 6weq
TitleDENV1 NS1 in complex with neutralizing 2B7 Fab fragment
Components
  • 2B7 Fab fragment heavy chain
  • 2B7 Fab fragment light chain
  • Non-structural protein 1
KeywordsVIRAL PROTEIN / Flavivirus NS1 / Antibody / Fab fragment
Function / homology
Function and homology information


symbiont-mediated suppression of host JAK-STAT cascade via inhibition of host TYK2 activity / host cell mitochondrion / symbiont-mediated suppression of host JAK-STAT cascade via inhibition of STAT2 activity / symbiont-mediated suppression of host cytoplasmic pattern recognition receptor signaling pathway via inhibition of MAVS activity / ribonucleoside triphosphate phosphatase activity / : / viral capsid / double-stranded RNA binding / protein complex oligomerization / monoatomic ion channel activity ...symbiont-mediated suppression of host JAK-STAT cascade via inhibition of host TYK2 activity / host cell mitochondrion / symbiont-mediated suppression of host JAK-STAT cascade via inhibition of STAT2 activity / symbiont-mediated suppression of host cytoplasmic pattern recognition receptor signaling pathway via inhibition of MAVS activity / ribonucleoside triphosphate phosphatase activity / : / viral capsid / double-stranded RNA binding / protein complex oligomerization / monoatomic ion channel activity / clathrin-dependent endocytosis of virus by host cell / mRNA (nucleoside-2'-O-)-methyltransferase activity / mRNA 5'-cap (guanine-N7-)-methyltransferase activity / RNA helicase activity / host cell endoplasmic reticulum membrane / protein dimerization activity / induction by virus of host autophagy / viral RNA genome replication / RNA-dependent RNA polymerase activity / serine-type endopeptidase activity / fusion of virus membrane with host endosome membrane / viral envelope / symbiont-mediated suppression of host type I interferon-mediated signaling pathway / host cell nucleus / virion attachment to host cell / virion membrane / structural molecule activity / proteolysis / extracellular region / ATP binding / membrane / metal ion binding
Similarity search - Function
: / Flavivirus envelope glycoprotein E, stem/anchor domain / RNA-directed RNA polymerase, thumb domain, Flavivirus / Flavivirus RNA-directed RNA polymerase, thumb domain / Flavivirus capsid protein C superfamily / : / Flavivirus non-structural protein NS2B / Flavivirus NS3 helicase, C-terminal helical domain / Genome polyprotein, Flavivirus / Flavivirus non-structural protein NS4A ...: / Flavivirus envelope glycoprotein E, stem/anchor domain / RNA-directed RNA polymerase, thumb domain, Flavivirus / Flavivirus RNA-directed RNA polymerase, thumb domain / Flavivirus capsid protein C superfamily / : / Flavivirus non-structural protein NS2B / Flavivirus NS3 helicase, C-terminal helical domain / Genome polyprotein, Flavivirus / Flavivirus non-structural protein NS4A / Flavivirus non-structural protein NS2B / Flavivirus capsid protein C / Flavivirus non-structural protein NS4B / mRNA cap 0/1 methyltransferase / Flavivirus capsid protein C / Flavivirus non-structural protein NS4B / Flavivirus non-structural protein NS4A / Flavivirus NS2B domain profile. / mRNA cap 0 and cap 1 methyltransferase (EC 2.1.1.56 and EC 2.1.1.57) domain profile. / Flavivirus non-structural protein NS2A / Flavivirus non-structural protein NS2A / Flavivirus NS3, petidase S7 / Peptidase S7, Flavivirus NS3 serine protease / Flavivirus NS3 protease (NS3pro) domain profile. / Envelope glycoprotein M, flavivirus / Flavivirus envelope glycoprotein M / RNA-directed RNA polymerase, flavivirus / Flavivirus RNA-directed RNA polymerase, fingers and palm domains / Flavivirus non-structural Protein NS1 / Flavivirus non-structural protein NS1 / Envelope glycoprotein M superfamily, flavivirus / Flavivirus polyprotein propeptide / Flavivirus polyprotein propeptide superfamily / Flavivirus polyprotein propeptide / Flaviviral glycoprotein E, central domain, subdomain 1 / Flaviviral glycoprotein E, central domain, subdomain 2 / Flavivirus envelope glycoprotein E, Stem/Anchor domain / Flavivirus glycoprotein E, immunoglobulin-like domain / Flavivirus envelope glycoprotein E, Stem/Anchor domain superfamily / Flavivirus glycoprotein, immunoglobulin-like domain / Flavivirus glycoprotein central and dimerisation domain / Flavivirus glycoprotein, central and dimerisation domains / Ribosomal RNA methyltransferase, FtsJ domain / FtsJ-like methyltransferase / Flavivirus/Alphavirus glycoprotein, immunoglobulin-like domain superfamily / Flavivirus glycoprotein, central and dimerisation domain superfamily / Flaviviral glycoprotein E, dimerisation domain / DEAD box, Flavivirus / Flavivirus DEAD domain / helicase superfamily c-terminal domain / Immunoglobulin E-set / Superfamilies 1 and 2 helicase C-terminal domain profile. / Superfamilies 1 and 2 helicase ATP-binding type-1 domain profile. / DEAD-like helicases superfamily / Helicase, C-terminal / Helicase superfamily 1/2, ATP-binding domain / RNA-directed RNA polymerase, catalytic domain / RdRp of positive ssRNA viruses catalytic domain profile. / S-adenosyl-L-methionine-dependent methyltransferase superfamily / Peptidase S1, PA clan, chymotrypsin-like fold / Peptidase S1, PA clan / DNA/RNA polymerase superfamily / P-loop containing nucleoside triphosphate hydrolase
Similarity search - Domain/homology
Biological speciesDengue virus 1
Mus musculus (house mouse)
MethodX-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution: 3.2 Å
AuthorsAkey, D.L. / Smith, J.L.
Funding support United States, 1items
OrganizationGrant numberCountry
National Institutes of Health/National Institute Of Allergy and Infectious Diseases (NIH/NIAID) United States
CitationJournal: Science / Year: 2021
Title: Structural basis for antibody inhibition of flavivirus NS1-triggered endothelial dysfunction.
Authors: Biering, S.B. / Akey, D.L. / Wong, M.P. / Brown, W.C. / Lo, N.T.N. / Puerta-Guardo, H. / Tramontini Gomes de Sousa, F. / Wang, C. / Konwerski, J.R. / Espinosa, D.A. / Bockhaus, N.J. / ...Authors: Biering, S.B. / Akey, D.L. / Wong, M.P. / Brown, W.C. / Lo, N.T.N. / Puerta-Guardo, H. / Tramontini Gomes de Sousa, F. / Wang, C. / Konwerski, J.R. / Espinosa, D.A. / Bockhaus, N.J. / Glasner, D.R. / Li, J. / Blanc, S.F. / Juan, E.Y. / Elledge, S.J. / Mina, M.J. / Beatty, P.R. / Smith, J.L. / Harris, E.
History
DepositionApr 2, 2020Deposition site: RCSB / Processing site: RCSB
Revision 1.0Dec 23, 2020Provider: repository / Type: Initial release
Revision 1.1Jan 20, 2021Group: Database references / Experimental preparation / Category: citation / citation_author / exptl_crystal_grow
Item: _citation.journal_volume / _citation.page_first ..._citation.journal_volume / _citation.page_first / _citation.page_last / _citation.pdbx_database_id_PubMed / _citation.title / _citation.year / _citation_author.identifier_ORCID / _exptl_crystal_grow.temp
Revision 1.2Oct 18, 2023Group: Data collection / Database references / Refinement description
Category: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model
Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession

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Structure visualization

Structure viewerMolecule:
MolmilJmol/JSmol

Downloads & links

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Assembly

Deposited unit
A: Non-structural protein 1
B: Non-structural protein 1
C: Non-structural protein 1
D: Non-structural protein 1
E: 2B7 Fab fragment heavy chain
F: 2B7 Fab fragment light chain
G: 2B7 Fab fragment heavy chain
H: 2B7 Fab fragment light chain
I: 2B7 Fab fragment heavy chain
J: 2B7 Fab fragment light chain
K: 2B7 Fab fragment heavy chain
L: 2B7 Fab fragment light chain
hetero molecules


Theoretical massNumber of molelcules
Total (without water)392,46921
Polymers390,60412
Non-polymers1,8669
Water0
1
A: Non-structural protein 1
B: Non-structural protein 1
E: 2B7 Fab fragment heavy chain
F: 2B7 Fab fragment light chain
G: 2B7 Fab fragment heavy chain
H: 2B7 Fab fragment light chain
hetero molecules


Theoretical massNumber of molelcules
Total (without water)196,18710
Polymers195,3026
Non-polymers8854
Water0
TypeNameSymmetry operationNumber
identity operation1_555x,y,z1
2
C: Non-structural protein 1
D: Non-structural protein 1
I: 2B7 Fab fragment heavy chain
J: 2B7 Fab fragment light chain
K: 2B7 Fab fragment heavy chain
L: 2B7 Fab fragment light chain
hetero molecules


Theoretical massNumber of molelcules
Total (without water)196,28311
Polymers195,3026
Non-polymers9815
Water0
TypeNameSymmetry operationNumber
identity operation1_555x,y,z1
Unit cell
Length a, b, c (Å)67.446, 329.709, 86.717
Angle α, β, γ (deg.)90.000, 90.783, 90.000
Int Tables number4
Space group name H-MP1211
Space group name HallP2yb
Symmetry operation#1: x,y,z
#2: -x,y+1/2,-z
Noncrystallographic symmetry (NCS)NCS domain:
IDEns-ID
11
21
31
41
12
22
32
42
13
23
33
43

NCS domain segments:
Dom-IDComponent-IDEns-IDSelection detailsAuth asym-IDAuth seq-ID
111chain 'A'A-10 - 108
121chain 'A'A129 - 349
131chain 'A'A401
141chain 'A'A421
251chain 'B'B-10 - 108
261chain 'B'B129 - 349
271chain 'B'B401
281chain 'B'B421
391chain 'C'C-10 - 108
3101chain 'C'C129 - 349
3111chain 'C'C401
3121chain 'C'C421
4131chain 'D'D-10 - 108
4141chain 'D'D129 - 349
4151chain 'D'D401
4161chain 'D'D421
1172(chain 'E' and (resid 2 through 132 or resid 136 through 219))E2 - 132
1182(chain 'E' and (resid 2 through 132 or resid 136 through 219))E136 - 162
1192(chain 'E' and (resid 2 through 132 or resid 136 through 219))E167 - 219
2202chain 'G'G2 - 132
2212chain 'G'G136 - 162
2222chain 'G'G167 - 219
3232chain 'I'I2 - 132
3242chain 'I'I136 - 162
3252chain 'I'I167 - 219
4262chain 'K'K2 - 132
4272chain 'K'K136 - 162
4282chain 'K'K167 - 219
1293chain 'F'F1 - 215
2303chain 'H'H1 - 215
3313chain 'J'J1 - 215
4323chain 'L'L1 - 215

NCS ensembles :
ID
1
2
3

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Components

#1: Protein
Non-structural protein 1


Mass: 42795.512 Da / Num. of mol.: 4
Source method: isolated from a genetically manipulated source
Source: (gene. exp.) Dengue virus 1 / Production host: unidentified baculovirus / References: UniProt: Q9J7C6
#2: Antibody
2B7 Fab fragment heavy chain


Mass: 28651.375 Da / Num. of mol.: 4 / Source method: isolated from a natural source / Source: (natural) Mus musculus (house mouse)
#3: Antibody
2B7 Fab fragment light chain


Mass: 26204.037 Da / Num. of mol.: 4 / Source method: isolated from a natural source / Source: (natural) Mus musculus (house mouse)
#4: Sugar
ChemComp-NAG / 2-acetamido-2-deoxy-beta-D-glucopyranose / N-acetyl-beta-D-glucosamine / 2-acetamido-2-deoxy-beta-D-glucose / 2-acetamido-2-deoxy-D-glucose / 2-acetamido-2-deoxy-glucose / N-ACETYL-D-GLUCOSAMINE / N-Acetylglucosamine


Type: D-saccharide, beta linking / Mass: 221.208 Da / Num. of mol.: 8
Source method: isolated from a genetically manipulated source
Formula: C8H15NO6
IdentifierTypeProgram
DGlcpNAcbCONDENSED IUPAC CARBOHYDRATE SYMBOLGMML 1.0
N-acetyl-b-D-glucopyranosamineCOMMON NAMEGMML 1.0
b-D-GlcpNAcIUPAC CARBOHYDRATE SYMBOLPDB-CARE 1.0
GlcNAcSNFG CARBOHYDRATE SYMBOLGMML 1.0
#5: Chemical ChemComp-SO4 / SULFATE ION / Sulfate


Mass: 96.063 Da / Num. of mol.: 1 / Source method: obtained synthetically / Formula: SO4
Has ligand of interestN

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Experimental details

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Experiment

ExperimentMethod: X-RAY DIFFRACTION / Number of used crystals: 1

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Sample preparation

CrystalDensity Matthews: 2.47 Å3/Da / Density % sol: 50.17 %
Crystal growTemperature: 293 K / Method: vapor diffusion, sitting drop / Details: 22% PEG 3350, 0.2 M trisodium citrate

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Data collection

DiffractionMean temperature: 100 K / Serial crystal experiment: N
Diffraction sourceSource: SYNCHROTRON / Site: APS / Beamline: 23-ID-B / Wavelength: 1.0332 Å
DetectorType: DECTRIS EIGER X 16M / Detector: PIXEL / Date: Jun 12, 2019
RadiationProtocol: SINGLE WAVELENGTH / Monochromatic (M) / Laue (L): M / Scattering type: x-ray
Radiation wavelengthWavelength: 1.0332 Å / Relative weight: 1
ReflectionResolution: 3.2→48.17 Å / Num. obs: 62008 / % possible obs: 99.7 % / Redundancy: 7.1 % / Biso Wilson estimate: 95.38 Å2 / CC1/2: 0.992 / CC star: 0.998 / Rmerge(I) obs: 0.3 / Rpim(I) all: 0.122 / Rrim(I) all: 0.3245 / Net I/av σ(I): 5.91 / Net I/σ(I): 5.91
Reflection shellResolution: 3.2→3.314 Å / Redundancy: 6.9 % / Rmerge(I) obs: 1.661 / Mean I/σ(I) obs: 0.87 / Num. unique obs: 6154 / CC1/2: 0.415 / CC star: 0.766 / Rpim(I) all: 0.6778 / Rrim(I) all: 1.795 / % possible all: 99.97

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Processing

Software
NameVersionClassification
JBluIce-EPICSdata collection
PHENIX1.17.1_3660refinement
XDSdata reduction
XDSdata scaling
PHASERphasing
RefinementMethod to determine structure: MOLECULAR REPLACEMENT
Starting model: 4o6b

4o6b


Resolution: 3.2→48.17 Å / SU ML: 0.5059 / Cross valid method: FREE R-VALUE / σ(F): 1.29 / Phase error: 27.2833
RfactorNum. reflection% reflection
Rfree0.2612 3092 4.99 %
Rwork0.207 --
obs0.2097 61969 99.9 %
Solvent computationShrinkage radii: 0.9 Å / VDW probe radii: 1.11 Å
Displacement parametersBiso mean: 93.17 Å2
Refinement stepCycle: LAST / Resolution: 3.2→48.17 Å
ProteinNucleic acidLigandSolventTotal
Num. atoms24052 0 5 0 24057
Refine LS restraints
Refine-IDTypeDev idealNumber
X-RAY DIFFRACTIONf_bond_d0.010824660
X-RAY DIFFRACTIONf_angle_d1.245133523
X-RAY DIFFRACTIONf_chiral_restr0.0623708
X-RAY DIFFRACTIONf_plane_restr0.00774265
X-RAY DIFFRACTIONf_dihedral_angle_d21.90718897
LS refinement shell
Resolution (Å)Rfactor RfreeNum. reflection RfreeRfactor RworkNum. reflection RworkRefine-ID% reflection obs (%)
3.2-3.250.38321210.35712689X-RAY DIFFRACTION100
3.25-3.30.36441220.35262658X-RAY DIFFRACTION99.96
3.3-3.360.38381470.32112716X-RAY DIFFRACTION99.97
3.36-3.420.34081380.28332623X-RAY DIFFRACTION99.89
3.42-3.490.34011420.26422672X-RAY DIFFRACTION99.96
3.49-3.560.31831320.26242719X-RAY DIFFRACTION100
3.56-3.640.30931400.26492655X-RAY DIFFRACTION99.96
3.64-3.720.36031300.26522667X-RAY DIFFRACTION99.86
3.72-3.810.30431440.25352690X-RAY DIFFRACTION99.89
3.81-3.920.26161300.25242684X-RAY DIFFRACTION99.86
3.92-4.030.28341480.23782661X-RAY DIFFRACTION99.96
4.03-4.160.25211640.21332653X-RAY DIFFRACTION99.86
4.16-4.310.22511400.18332674X-RAY DIFFRACTION99.89
4.31-4.480.21141320.1682703X-RAY DIFFRACTION100
4.48-4.690.21781350.16272643X-RAY DIFFRACTION100
4.69-4.930.21811360.15922686X-RAY DIFFRACTION99.96
4.93-5.240.23141530.16622699X-RAY DIFFRACTION100
5.24-5.650.24941620.17362654X-RAY DIFFRACTION100
5.65-6.210.25931300.17772709X-RAY DIFFRACTION100
6.21-7.110.25021530.18172648X-RAY DIFFRACTION99.89
7.11-8.950.21591510.18652685X-RAY DIFFRACTION99.96
8.95-48.170.25991420.19232689X-RAY DIFFRACTION98.88
Refinement TLS params.

Method: refined / Refine-ID: X-RAY DIFFRACTION

IDL11 (°2)L12 (°2)L13 (°2)L22 (°2)L23 (°2)L33 (°2)S11 (Å °)S12 (Å °)S13 (Å °)S21 (Å °)S22 (Å °)S23 (Å °)S31 (Å °)S32 (Å °)S33 (Å °)T11 (Å2)T12 (Å2)T13 (Å2)T22 (Å2)T23 (Å2)T33 (Å2)Origin x (Å)Origin y (Å)Origin z (Å)
12.141600490270.07630021480640.007109693342732.44710132316-0.2515191228961.938092204610.115869639936-0.149001141713-0.317457792569-0.0122837348033-0.01072508884840.1709887701120.271361388989-0.01514674510310.0001987336707150.596833795193-0.01875667112050.01029305792580.7223332884160.01113998832380.63243895309846.7872256446116.0390626633.80989119587
21.278843107180.2590484954940.2487363104871.7467687353-0.2131373742351.33503908704-0.170071594103-0.05240870773460.1484468192390.07859190474980.03994207845620.00030298813553-0.2379421034920.1517680191930.00120624240990.584689839661-0.0600823194197-0.009248971649090.751096636265-0.0292627198590.54506515738647.47464794151.105148964-5.83344810006
31.694059193690.1995113679790.1309906431132.34698993881-0.07504714399491.171922163090.006552641792720.02508744222880.2476268444420.07985551577220.01390566785080.241237787512-0.140252086871-0.01220177367610.0001219477399410.560969271076-0.04015581714030.05091632420550.7654196047090.05092880649890.59734444421847.0283132419163.44316799939.4262280294
41.688000051310.5992059116350.03912619720232.479508458340.1523246280771.099967696780.07490169468410.0446467881465-0.3490089245930.06870819903-0.137707441839-0.3600276046330.2899041080440.1339999235460.001089084589030.6923712096120.006157380997550.007612941163360.7124683072660.0004309845454590.61151134487248.4014935549128.30010201549.0238178059
51.97810166249-0.7100040877721.343961031021.023750170030.009985728194152.07378575221-0.0377623170036-0.0176429219161-0.3410611967790.4930610113920.0581844660365-0.2955327407550.0931522613040.0533087369195-0.002524937422220.9136300149280.0326046813573-0.115549814510.7744769192390.02678366182941.1150843516869.753019658590.066827059138.7464325659
61.798952215930.2976494277890.7136877169231.72611497321-0.7598958899110.9973871474050.465581476803-0.397532020812-0.6145594702930.28762642948-0.330938023585-0.1163754381550.741236295183-0.172041379838-0.0001727237279181.393795979360.0306106186691-0.1567500012710.8993991127780.09155735134631.1363622546164.445097672373.170715346333.6423198754
70.829924290795-0.6400517368670.1310525034482.028694729411.111628283641.85041226893-0.0750521188915-0.1330297672230.2851034370150.335028991479-0.1418835718730.595230678116-0.125809679793-0.388114343633-0.001056254004890.857053270316-0.00404698669629-0.01901836824940.910014335429-0.08660387001711.2092286810929.4547631225190.87997425413.1039843439
80.471903947243-0.0804919967964-0.4558873226252.3163344627-0.08203148378160.674653777572-0.0419236021803-0.04425589598990.463144938024-0.441516899040.02779416202220.245010825627-0.6328488280320.0929234986729-4.19175402718E-61.115447340190.00342988723457-0.1887722384050.796149005522-0.01263098602111.2068285249639.1817273307201.5421390591.85685182862
91.170406395910.168889716164-0.8798428319671.533231317490.5875072307711.915553978750.03704077300580.02359237190830.372338150823-0.5173915297220.109982431924-0.167304238786-0.1413566355530.0494279919145-0.002320695641480.854556111278-0.1146020601520.0608856518750.8871287950290.07871973470271.0025103935569.0482696735189.4681794264.33219970393
101.76507676918-0.469402906239-1.04904169452.275957803570.1894754832650.8110762206290.3283109187040.2393774238410.567164622948-0.736301171862-0.2418664428340.170681483992-0.710297792292-0.1784356626010.002411709545031.31204426077-0.1111545443880.009056055062730.9035089773540.03144499666881.0373948997963.3510363552206.2351269.132997554
111.173427131790.6493088340620.1139421863272.030557183230.9415020266211.61402504470.04366561125070.117202563023-0.3266986235690.017352259764-0.09733880802530.3161067137240.150528404014-0.275652198019-0.001353151481190.908828836475-0.0826086979127-0.02038173327070.911222919777-0.1182562585241.1132075933830.291266223988.322752098630.383955384
120.894819962149-0.348025328948-0.002115306387631.616282677880.09610266439450.934868537432-0.01456323875680.125106806667-0.4832226703270.232045976435-0.01246031658330.03244198744270.6125026738650.075657673059-0.000287574928291.36350344394-0.04183212218870.07495048582130.873466064606-0.05536353495751.1825098712940.371687757677.76849263141.5615867821
Refinement TLS group
IDRefine-IDRefine TLS-IDSelection details
1X-RAY DIFFRACTION1(chain 'A' and resid -10 through 401)
2X-RAY DIFFRACTION2(chain 'B' and resid -10 through 401)
3X-RAY DIFFRACTION3(chain 'C' and resid -10 through 401)
4X-RAY DIFFRACTION4(chain 'D' and resid -10 through 401)
5X-RAY DIFFRACTION5(chain 'E' and resid 2 through 219)
6X-RAY DIFFRACTION6(chain 'F' and resid 1 through 215)
7X-RAY DIFFRACTION7(chain 'G' and resid 2 through 219)
8X-RAY DIFFRACTION8(chain 'H' and resid 1 through 215)
9X-RAY DIFFRACTION9(chain 'I' and resid 2 through 219)
10X-RAY DIFFRACTION10(chain 'J' and resid 1 through 215)
11X-RAY DIFFRACTION11(chain 'K' and resid 2 through 219)
12X-RAY DIFFRACTION12(chain 'L' and resid 1 through 215)

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  • wwPDB released updated PDB data conforming to the new PDBx/mmCIF dictionary.
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  • In this update, many items about electron microscopy experimental information are reorganized (e.g. em_software).
  • Now, EM Navigator and Yorodumi are based on the updated data.

External links:wwPDB Remediation / Enriched Model Files Conforming to OneDep Data Standards Now Available in the PDB FTP Archive

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Yorodumi

Thousand views of thousand structures

  • Yorodumi is a browser for structure data from EMDB, PDB, SASBDB, etc.
  • This page is also the successor to EM Navigator detail page, and also detail information page/front-end page for Omokage search.
  • The word "yorodu" (or yorozu) is an old Japanese word meaning "ten thousand". "mi" (miru) is to see.

Related info.:EMDB / PDB / SASBDB / Comparison of 3 databanks / Yorodumi Search / Aug 31, 2016. New EM Navigator & Yorodumi / Yorodumi Papers / Jmol/JSmol / Function and homology information / Changes in new EM Navigator and Yorodumi

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