PDB-6fla: 3H5 Fab bound to EDIII of DenV 2 Xtal form 1

ID or keywords:

Entry

Database: PDB / ID: 6fla

Title

3H5 Fab bound to EDIII of DenV 2 Xtal form 1

Components

(Domain III of Dengue virus ...) x 2
Heavy chain
Light Chain of 3H5

Keywords

VIRAL PROTEIN /

Dengue virus /

antibody / macromolecular complex

Function / homology

Function and homology information

symbiont-mediated suppression of host JAK-STAT cascade via inhibition of host TYK2 activity /

flavivirin / host cell mitochondrion / symbiont-mediated suppression of host JAK-STAT cascade via inhibition of STAT2 activity / symbiont-mediated suppression of host cytoplasmic pattern recognition receptor signaling pathway via inhibition of MAVS activity / : /

viral capsid / nucleoside-triphosphate phosphatase /

double-stranded RNA binding / protein complex oligomerization ...
Similarity search - Function

Immunoglobulin-like - #350 / : / Flavivirus envelope glycoprotein E, stem/anchor domain /

RNA-directed RNA polymerase, thumb domain, Flavivirus / Flavivirus RNA-directed RNA polymerase, thumb domain / Flavivirus capsid protein C superfamily / : / Flavivirus non-structural protein NS2B / Flavivirus NS3 helicase, C-terminal helical domain / Genome polyprotein, Flavivirus ...Immunoglobulin-like - #350 / : / Flavivirus envelope glycoprotein E, stem/anchor domain /

RNA-directed RNA polymerase, thumb domain, Flavivirus / Flavivirus RNA-directed RNA polymerase, thumb domain / Flavivirus capsid protein C superfamily / : / Flavivirus non-structural protein NS2B / Flavivirus NS3 helicase, C-terminal helical domain / Genome polyprotein, Flavivirus / Flavivirus non-structural protein NS4A / Flavivirus non-structural protein NS2B / Flavivirus capsid protein C / Flavivirus non-structural protein NS4B / mRNA cap 0/1 methyltransferase / Flavivirus capsid protein C / Flavivirus non-structural protein NS4B / Flavivirus non-structural protein NS4A / Flavivirus NS2B domain profile. / mRNA cap 0 and cap 1 methyltransferase (EC 2.1.1.56 and EC 2.1.1.57) domain profile. / Flavivirus non-structural protein NS2A / Flavivirus non-structural protein NS2A / Flavivirus NS3, petidase S7 / Peptidase S7, Flavivirus NS3 serine protease / Flavivirus NS3 protease (NS3pro) domain profile. / Envelope glycoprotein M, flavivirus / Flavivirus envelope glycoprotein M /

RNA-directed RNA polymerase, flavivirus / Flavivirus RNA-directed RNA polymerase, fingers and palm domains / Flavivirus non-structural Protein NS1 / Flavivirus non-structural protein NS1 / Envelope glycoprotein M superfamily, flavivirus / Flavivirus polyprotein propeptide / Flavivirus polyprotein propeptide superfamily / Flavivirus polyprotein propeptide / Flaviviral glycoprotein E, central domain, subdomain 1 / Flaviviral glycoprotein E, central domain, subdomain 2 / Flavivirus envelope glycoprotein E, Stem/Anchor domain / Flavivirus glycoprotein E, immunoglobulin-like domain / Flavivirus envelope glycoprotein E, Stem/Anchor domain superfamily / Flavivirus glycoprotein, immunoglobulin-like domain / Flavivirus glycoprotein central and dimerisation domain / Flavivirus glycoprotein, central and dimerisation domains / Ribosomal RNA methyltransferase, FtsJ domain / FtsJ-like methyltransferase / Flavivirus/Alphavirus glycoprotein, immunoglobulin-like domain superfamily / Flavivirus glycoprotein, central and dimerisation domain superfamily / Flaviviral glycoprotein E, dimerisation domain /

DEAD box, Flavivirus / Flavivirus DEAD domain / helicase superfamily c-terminal domain / Immunoglobulin E-set / Superfamilies 1 and 2 helicase C-terminal domain profile. / Superfamilies 1 and 2 helicase ATP-binding type-1 domain profile. / DEAD-like helicases superfamily /

Helicase, C-terminal / Helicase superfamily 1/2, ATP-binding domain /

RNA-directed RNA polymerase, catalytic domain / RdRp of positive ssRNA viruses catalytic domain profile. / S-adenosyl-L-methionine-dependent methyltransferase superfamily /

Immunoglobulins / Peptidase S1, PA clan, chymotrypsin-like fold / Peptidase S1, PA clan / DNA/RNA polymerase superfamily /

Immunoglobulin-like /

Sandwich / P-loop containing nucleoside triphosphate hydrolase / Mainly Beta
Similarity search - Domain/homology

Biological species

Mus musculus (house mouse)

Dengue virus 2

Method

X-RAY DIFFRACTION /

SYNCHROTRON /

MOLECULAR REPLACEMENT / Resolution: 2.9 Å

Authors

Flanagan, A. / Renner, M. / Grimes, J.M.

Funding support

United Kingdom, 2items

Citation

Journal: Nat. Immunol. / Year: 2018
Title: Characterization of a potent and highly unusual minimally enhancing antibody directed against dengue virus.
Authors: Renner, M. / Flanagan, A. / Dejnirattisai, W. / Puttikhunt, C. / Kasinrerk, W. / Supasa, P. / Wongwiwat, W. / Chawansuntati, K. / Duangchinda, T. / Cowper, A. / Midgley, C.M. / Malasit, P. / ...

History

Deposition	Jan 25, 2018	Deposition site: PDBE / Processing site: PDBE
Revision 1.0	Oct 24, 2018	Provider: repository / Type: Initial release
Revision 1.1	Oct 31, 2018	Group: Data collection / Database references / Category: citation Item: _citation.journal_volume / _citation.page_first / _citation.page_last
Revision 1.2	Apr 3, 2019	Group: Data collection / Source and taxonomy / Category: entity_src_gen / Item: _entity_src_gen.pdbx_host_org_cell_line

Structure viewer	Molecule: MolmilJmol/JSmol

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Download

PDBx/mmCIF format	6fla.cif.gz	408.5 KB	Display	PDBx/mmCIF format
PDB format	pdb6fla.ent.gz	350.1 KB	Display	PDB format
PDBx/mmJSON format	6fla.json.gz		Tree view	PDBx/mmJSON format
Others	Other downloads

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Validation report

Arichive directory	https://data.pdbj.org/pub/pdb/validation_reports/fl/6fla ftp://data.pdbj.org/pub/pdb/validation_reports/fl/6fla	HTTPS FTP

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Related structure data

Related structure data	6flbC 6flcC C: citing same article (ref.)
Similar structure data	6o9h-2 6o3b-2 6svl-1 6plk-2 4l5f-d 6p50-d 5xxy-d 1tqc-d 6flb-d 6o9h-1 Search similar-shape structures by Omokage search (details) Search similar-shape structures by Omokage search (details) Search similar-shape structures by Omokage search (details) Similarity search - Function & homologyF&H Search Similarity search - FunctionF&H Search Similarity search - HomologyF&H Search

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Links

PDB pages	PDBj / wwPDB / NCBI
Related items in Molecule of the Month	#103 - Jul 2008 Dengue Virus similarity (44) #21 - Sep 2001 Antibodies similarity (1) #256 - Apr 2021 SARS-CoV-2 Spike and Antibodies similarity (1) #197 - May 2016 Zika Virus similarity (43) #145 - Jan 2012 Messenger RNA Capping similarity (1)

Deposited unit

A: Heavy chain

B: Light Chain of 3H5

G: Domain III of Dengue virus 2

H: Heavy chain

I: Domain III of Dengue virus 2

L: Light Chain of 3H5

hetero molecules

120 kDa, 6 polymers
Search similar-shape structures of this assembly by Omokage search (details)

1

A: Heavy chain

B: Light Chain of 3H5

G: Domain III of Dengue virus 2

hetero molecules

defined by author&software
Evidence: gel filtration
59.6 kDa, 3 polymers
Search similar-shape structures of this assembly by Omokage search (details)

2

H: Heavy chain

I: Domain III of Dengue virus 2

L: Light Chain of 3H5

hetero molecules

defined by author&software
60 kDa, 3 polymers
Search similar-shape structures of this assembly by Omokage search (details)

Unit cell

Length a, b, c (Å)	40.840, 263.870, 272.830
Angle α, β, γ (deg.)	90.00, 90.00, 90.00
Int Tables number	20
Space group name H-M	C222₁

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Domain III of Dengue virus ... , 2 types, 2 molecules GI

#3: Protein	Domain III of Dengue virus 2 Mass: 11063.860 Da / Num. of mol.: 1 Source method: isolated from a genetically manipulated source Source: (gene. exp.) Dengue virus 2 / Production host: Escherichia coli (E. coli) / References: UniProt: P14340, UniProt: W5RZ25*PLUS
#4: Protein	Domain III of Dengue virus 2 Mass: 11295.068 Da / Num. of mol.: 1 Source method: isolated from a genetically manipulated source Source: (gene. exp.) Dengue virus 2 / Production host: Escherichia coli (E. coli) / References: UniProt: P29991, UniProt: W5RZ25*PLUS

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Antibody , 2 types, 4 molecules AHBL

#1: Antibody	Heavy chain Mass: 24438.215 Da / Num. of mol.: 2 Source method: isolated from a genetically manipulated source Source: (gene. exp.) Mus musculus (house mouse) / Cell line (production host): HEK293T / Production host: Homo sapiens (human)
#2: Antibody	Light Chain of 3H5 Mass: 24030.584 Da / Num. of mol.: 2 Source method: isolated from a genetically manipulated source Source: (gene. exp.) Mus musculus (house mouse) / Cell line (production host): HEK293T / Production host: Homo sapiens (human)

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Non-polymers , 2 types, 4 molecules

#5: Chemical	ChemComp-CL / CHLORIDE ION / Chloride Mass: 35.453 Da / Num. of mol.: 2 / Source method: obtained synthetically / Formula: Cl
#6: Chemical	ChemComp-GOL / GLYCEROL / GLYCERIN / PROPANE-1,2,3-TRIOL / Glycerol Mass: 92.094 Da / Num. of mol.: 2 / Source method: obtained synthetically / Formula: C₃H₈O₃

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Experiment

Experiment	Method: X-RAY DIFFRACTION / Number of used crystals: 1

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Sample preparation

Crystal	Density Matthews: 3.18 Å³/Da / Density % sol: 61.27 %
Crystal grow	Temperature: 293 K / Method: vapor diffusion, sitting drop Details: 20% w/v PEG 3350, 0.2 M di-Sodium Tartrate at a protein concentration of 4.16 mg/ml

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Data collection

Diffraction	Mean temperature: 100 K
Diffraction source	Source: SYNCHROTRON / Site: Diamond / Beamline: I02 / Wavelength: 0.951 Å
Detector	Type: ADSC QUANTUM 315 / Detector: CCD / Date: Mar 12, 2008
Radiation	Protocol: SINGLE WAVELENGTH / Monochromatic (M) / Laue (L): M / Scattering type: x-ray
Radiation wavelength	Wavelength: 0.951 Å / Relative weight: 1
Reflection	Resolution: 2.9→40 Å / Num. obs: 33359 / % possible obs: 100 % / Redundancy: 9.7 % / B_iso Wilson estimate: 81.22 Å² / Net I/σ(I): 20.5
Reflection shell	Resolution: 2.9→3 Å

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Processing

Software

Name	Version	Classification
BUSTER	2.11.1	refinement
xia2		data reduction
xia2		data scaling
PHASER		phasing

Refinement

Method to determine structure:

MOLECULAR REPLACEMENT / Resolution: 2.9→39.59 Å / Cor.coef. F_o:F_c: 0.9296 / Cor.coef. F_o:F_c free: 0.917 / SU R Cruickshank DPI: 1.897 / Cross valid method: THROUGHOUT / σ(F): 0 / SU R Blow DPI: 1.75 / SU R_free Blow DPI: 0.311 / SU R_free Cruickshank DPI: 0.317

	R_factor	Num. reflection	% reflection	Selection details
R_free	0.2211	1689	5.06 %	RANDOM
R_work	0.2032	-	-	-
obs	0.2042	33359	99.04 %	-

Displacement parameters

B_iso mean: 67.62 Å²

	B_aniso -1	B_aniso -2	B_aniso -3
1-	-5.2265 Å²	0 Å²	0 Å²
2-	-	4.6548 Å²	0 Å²
3-	-	-	0.5717 Å²

Refine analyze

Luzzati coordinate error obs: 0.448 Å

Refinement step

Cycle: 1 / Resolution: 2.9→39.59 Å

	Protein	Nucleic acid	Ligand	Solvent	Total
Num. atoms	8129	0	14	0	8143

Refine LS restraints

Refine-ID	Type	Dev ideal	Number	Restraint function	Weight
X-RAY DIFFRACTION	t_bond_d	0.01	8344	HARMONIC	2
X-RAY DIFFRACTION	t_angle_deg	1.27	11350	HARMONIC	2
X-RAY DIFFRACTION	t_dihedral_angle_d		2784	SINUSOIDAL	2
X-RAY DIFFRACTION	t_incorr_chiral_ct
X-RAY DIFFRACTION	t_pseud_angle
X-RAY DIFFRACTION	t_trig_c_planes		188	HARMONIC	2
X-RAY DIFFRACTION	t_gen_planes		1201	HARMONIC	5
X-RAY DIFFRACTION	t_it		8344	HARMONIC	20
X-RAY DIFFRACTION	t_nbd
X-RAY DIFFRACTION	t_omega_torsion	3.42
X-RAY DIFFRACTION	t_other_torsion	18.58
X-RAY DIFFRACTION	t_improper_torsion
X-RAY DIFFRACTION	t_chiral_improper_torsion		1121	SEMIHARMONIC	5
X-RAY DIFFRACTION	t_sum_occupancies
X-RAY DIFFRACTION	t_utility_distance
X-RAY DIFFRACTION	t_utility_angle
X-RAY DIFFRACTION	t_utility_torsion
X-RAY DIFFRACTION	t_ideal_dist_contact		8794	SEMIHARMONIC	4

LS refinement shell

Resolution: 2.9→2.99 Å / Total num. of bins used: 17

	R_factor	Num. reflection	% reflection
R_free	0.3302	148	5.57 %
R_work	0.3167	2508	-
all	0.3175	2656	-
obs	-	-	99.04 %

Refinement TLS params.

Method: refined / Refine-ID: X-RAY DIFFRACTION

ID	L11 (°²)	L12 (°²)	L13 (°²)	L22 (°²)	L23 (°²)	L33 (°²)	S11 (Å °)	S12 (Å °)	S13 (Å °)	S21 (Å °)	S22 (Å °)	S23 (Å °)	S31 (Å °)	S32 (Å °)	S33 (Å °)	T11 (Å²)	T12 (Å²)	T13 (Å²)	T22 (Å²)	T23 (Å²)	T33 (Å²)	Origin x (Å)	Origin y (Å)	Origin z (Å)
1	1.0805	-0.1598	-0.1311	1.5784	-1.0967	2.7183	-0.0117	-0.0778	0.0152	0.1117	-0.0207	0.0391	0.0722	0.1406	0.0325	-0.1198	0.1058	0.0285	0.1247	-0.1052	-0.0455	31.8477	-108.984	-37.1755
2	0.0492	-0.2328	-0.7306	1.5629	-1.7497	0.5844	-0.0036	-0.0042	-0.0234	-0.0016	0.0009	-0.0089	0.0082	-0.0385	0.0028	0.0542	0.0425	0.0467	-0.0169	0.0559	-0.0148	36.2878	-135.162	-38.6718
3	0.0754	0.2707	-1.1607	3.2806	-1.8934	2.0281	0	0.0036	0.0103	0.0535	-0.0107	-0.0054	-0.0491	0.0667	0.0106	0.1175	-0.0108	0.152	-0.0908	0.152	-0.0369	41.6845	-137.025	-46.9205
4	0.0999	0.358	-0.3104	0.097	-0.0533	0	0.0006	0.0023	0.0005	0.0044	-0.0021	0.0008	-0.0014	0.0015	0.0015	0.0041	-0.0028	0.0079	0.0121	0.0279	0.0005	48.4796	-142.945	-42.9385
5	0.9571	-0.6418	1.1887	0	0.1637	0.4695	0.0018	-0.0167	0.0322	-0.0531	-0.0212	0.0206	0.0473	0.0016	0.0194	0.0261	0.0329	-0.0784	0.0081	-0.0174	0.0067	20.9308	-113.3	-61.783
6	0	1.1631	-0.0405	2.2614	0.1539	3.3754	-0.0025	-0.0039	0.0798	-0.1237	-0.0299	0.0416	0.1208	0.0312	0.0324	0.0266	0.1103	-0.0164	-0.0577	-0.0056	-0.029	27.8629	-107.903	-57.871
7	0.0084	-1.9632	-0.839	1.6768	2.2449	0.89	-0.0005	0.0066	-0.0851	0.0058	-0.0129	-0.028	0.0071	-0.0103	0.0134	0.0573	0.0188	0.1265	-0.1024	0.0776	0.0108	36.0604	-144.886	-53.3323
8	1.2507	0.436	-1.3652	0.8173	0.2638	2.1173	-0.0048	-0.0291	-0.1276	0.012	-0.0334	0.0652	-0.0037	-0.1154	0.0382	0.0886	0.01	0.1416	-0.1489	0.0619	0.0474	29.4337	-146.85	-55.2831
9	0.225	1.5562	-0.5138	1.107	-0.9657	2.7513	-0.026	0.0896	-0.0119	-0.0848	0.0565	-0.0311	-0.0589	-0.0532	-0.0306	0.0444	-0.0278	0.0527	-0.0169	0.152	-0.0292	41.2008	-42.4102	-33.2197
10	0.8567	1.1359	0.1628	0.7931	-1.3167	1.0091	-0.0228	0.0127	0.0098	-0.0726	0.0144	0.0079	0.0405	-0.0875	0.0084	0.0446	0.0325	0.0529	0.0254	0.152	-0.0379	39.0363	-46.0873	-32.7518
11	0.0468	0.2862	-0.7902	1.1994	0.3111	1.9983	-0.0165	-0.0221	-0.05	-0.1739	0.0907	-0.0113	-0.0134	-0.0696	-0.0743	0.057	-0.0457	0.035	0.0076	0.0118	-0.0716	22.9007	-68.4886	-21.8833
12	0.1563	0.3184	0.8143	0.0377	0.3834	0.4809	-0.0004	-0.0142	-0.0048	-0.0311	0.0088	-0.0102	-0.0271	-0.0139	-0.0084	0.0679	-0.0148	-0.0636	0.0352	0.0687	-0.0663	16.9825	-66.2508	-27.5875
13	1.5026	-0.384	0.3488	1.496	-1.6244	1.207	-0.0039	-0.0361	-0.0454	0.0145	0.0133	-0.016	-0.0781	0.049	-0.0094	0.001	-0.0441	0.0346	-0.0253	0.1266	0.0325	46.6964	-44.1047	-11.3186
14	0.107	-0.114	0.3835	0	-0.3213	0.0903	0.0009	-0.0055	-0.0035	0.0055	0.0043	-0.0061	0.001	0.0002	-0.0052	-0.011	-0.0275	-0.048	0.0126	0.0504	0.0192	54.3247	-40.2741	-7.6368
15	1.2394	0.328	-0.4148	1.3881	-0.2691	0.3474	-0.0059	-0.0071	-0.0582	-0.0231	-0.0404	-0.0628	0.0733	0.0018	0.0463	-0.0102	-0.0209	0.0268	-0.0435	0.0534	-0.0212	36.6333	-62.9187	-14.0372
16	1.0092	-0.8186	0.6912	0.9935	0.2944	0.4822	-0.0094	0.0362	-0.0895	-0.0409	-0.0121	-0.0408	0.0938	0.025	0.0215	0.0585	-0.0774	0.152	-0.0858	0.0186	0.0531	31.0806	-80.8024	-16.1386
17	0	-0.0477	-0.0746	0.1373	0.0157	0	0.0012	-0.0105	0.0013	-0.0068	-0.0007	-0.001	0.0019	0.0019	-0.0004	0.0052	-0.0052	0.0089	-0.0181	-0.0588	0.0069	33.1417	-89.5216	-45.9387
18	0	0.0149	0.4281	0.0357	0.375	0.146	0.0001	0.0038	-0.0036	0.0011	0.0062	0.0027	-0.0032	-0.0006	-0.0063	0.0253	-0.0173	0.0155	-0.0064	0.0021	-0.0101	24.6932	-73.6257	-38.9867
19	0.7969	1.5662	-0.1347	0.6785	-0.1554	0.1497	0.0028	0.001	-0.0073	-0.0036	0.002	-0.0023	-0.0124	0.0104	-0.0048	-0.0088	-0.0159	0.0322	0.0167	-0.0274	0.0355	31.3165	-80.2873	-43.6469
20	0	0.1612	-0.0175	0.5741	0.7346	0.2778	0.0002	-0.0013	-0.004	-0.0107	0.001	0.0029	-0.009	0.0008	-0.0012	0.0069	0.0069	0.0137	-0.0042	-0.0343	0.0151	22.9806	-85.469	-49.7236
21	0.0465	-0.1991	0.1773	0.2584	0.0292	0.0808	-0.0003	0.0052	-0.0054	-0.005	-0.0042	0.0081	-0.0017	-0.0006	0.0045	0.0085	0.0108	-0.0131	-0.0012	0.0032	0.0139	19.7418	-80.9873	-52.8727
22	0.0204	0.0224	0.1226	0	0.0809	0	0.0004	-0.0027	0.001	0.0084	-0.0032	-0.0107	0.0001	0.0075	0.0029	-0.0061	-0.0263	0.012	-0.0019	-0.0241	0.0152	38.6932	-81.5733	-45.4967
23	0.4517	0.6506	0.7128	0.494	0.7185	0	0.0004	0.0142	-0.0017	-0.0069	0.0106	0.011	-0.0099	-0.0206	-0.011	0.0226	-0.0035	0.0356	-0.019	-0.0465	0.0354	20.5594	-81.4855	-45.9406
24	0.1819	0.2865	-0.4781	0.1271	-0.0377	0	-0.0013	0.0079	0.0032	0.0002	0.0061	0.006	-0.0013	-0.0108	-0.0048	-0.0024	0.0095	0.0719	-0.0043	-0.0264	0.0236	17.6134	-80.9863	-41.4593
25	0	-0.0348	0.1125	0.3045	0.1257	0.0551	0.0006	-0.0006	-0.0004	-0.0006	0.0003	-0.0006	-0.0033	-0.0001	-0.0009	0.0346	0.0047	0.0314	-0.0146	0.0445	0.0017	45.9753	-23.2323	-24.8699
26	0	0.1391	0.1237	0.0684	-0.365	0	0.0001	-0.0058	-0.0056	0.0018	0.0035	0.0056	-0.0042	0.0132	-0.0036	0.0021	-0.0016	0.0234	0.0071	0.0373	0.001	58.8613	-10.3001	-30.6245
27	0.3635	-1.1798	-0.1306	0.7009	-0.2236	0.0557	-0.0012	-0.0067	0.0034	0.0125	0.0097	-0.0148	-0.013	-0.0051	-0.0085	0.01	0.0166	0.0414	-0.0091	0.0591	0.0184	50.443	-15.2206	-26.5205
28	0.0706	0.3582	-0.1582	0.8228	-0.3315	0.3082	0.0007	-0.0022	-0.0009	0.0048	-0.0054	-0.006	-0.0097	-0.0089	0.0048	-0.0049	0.0173	0.0267	-0.011	0.0437	0.0284	52.501	-21.2845	-19.1756
29	0.0046	-0.0151	0.0008	0	0.0148	0	-0.0001	-0.0016	-0.0017	0.002	-0.0003	-0.0021	0.0013	0.0057	0.0004	-0.0105	0.0203	0.0071	0.0008	0.0157	0.023	66.876	-29.3854	-19.4748
30	0	0.2732	0.09	0	-0.1512	0	0.0016	0.0001	0.0106	0.0131	0.0062	0.0001	-0.0113	-0.0009	-0.0078	0.0281	-0.0196	0.0422	-0.0187	0.0154	0.0032	51.3917	-14.7752	-18.5629
31	0.1521	0.2814	-0.387	1.4555	-0.2176	0.236	-0.0007	0.0051	-0.0084	-0.008	0.0084	-0.0125	0.0017	0.0057	-0.0077	0.0026	-0.0025	0.0103	-0.0071	0.0255	0.0379	58.526	-15.7255	-24.2513
32	0.153	-0.4768	0.0452	0.5206	-0.3546	0.0428	0.0022	0.0008	0.0074	-0.0042	0.0133	-0.0263	0.0146	0.0112	-0.0155	-0.0018	-0.0352	0.0521	-0.0026	0.0591	0.0164	59.1563	-22.7641	-27.0037

Refinement TLS group

ID	Refine-ID	Refine TLS-ID	Selection details
1	X-RAY DIFFRACTION	1	{ A\|2 - A\|108 }
2	X-RAY DIFFRACTION	2	{ A\|109 - A\|137 }
3	X-RAY DIFFRACTION	3	{ A\|138 - A\|207 }
4	X-RAY DIFFRACTION	4	{ A\|208 - A\|217 }
5	X-RAY DIFFRACTION	5	{ B\|1 - B\|26 }
6	X-RAY DIFFRACTION	6	{ B\|27 - B\|110 }
7	X-RAY DIFFRACTION	7	{ B\|111 - B\|142 }
8	X-RAY DIFFRACTION	8	{ B\|143 - B\|215 }
9	X-RAY DIFFRACTION	9	{ H\|2 - H\|71 }
10	X-RAY DIFFRACTION	10	{ H\|72 - H\|119 }
11	X-RAY DIFFRACTION	11	{ H\|120 - H\|194 }
12	X-RAY DIFFRACTION	12	{ H\|195 - H\|217 }
13	X-RAY DIFFRACTION	13	{ L\|1 - L\|67 }
14	X-RAY DIFFRACTION	14	{ L\|68 - L\|77 }
15	X-RAY DIFFRACTION	15	{ L\|78 - L\|151 }
16	X-RAY DIFFRACTION	16	{ L\|152 - L\|215 }
17	X-RAY DIFFRACTION	17	{ G\|300 - G\|307 }
18	X-RAY DIFFRACTION	18	{ G\|308 - G\|316 }
19	X-RAY DIFFRACTION	19	{ G\|317 - G\|331 }
20	X-RAY DIFFRACTION	20	{ G\|332 - G\|343 }
21	X-RAY DIFFRACTION	21	{ G\|344 - G\|355 }
22	X-RAY DIFFRACTION	22	{ G\|356 - G\|365 }
23	X-RAY DIFFRACTION	23	{ G\|366 - G\|384 }
24	X-RAY DIFFRACTION	24	{ G\|385 - G\|394 }
25	X-RAY DIFFRACTION	25	{ I\|300 - I\|308 }
26	X-RAY DIFFRACTION	26	{ I\|309 - I\|316 }
27	X-RAY DIFFRACTION	27	{ I\|317 - I\|330 }
28	X-RAY DIFFRACTION	28	{ I\|331 - I\|341 }
29	X-RAY DIFFRACTION	29	{ I\|342 - I\|346 }
30	X-RAY DIFFRACTION	30	{ I\|347 - I\|361 }
31	X-RAY DIFFRACTION	31	{ I\|362 - I\|378 }
32	X-RAY DIFFRACTION	32	{ I\|379 - I\|394 }

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Domain III of Dengue virus ... , 2 types, 2 molecules GI

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