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Yorodumi- PDB-4pj1: Crystal structure of the human mitochondrial chaperonin symmetric... -
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-Basic information
Entry | Database: PDB / ID: 4pj1 | |||||||||
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Title | Crystal structure of the human mitochondrial chaperonin symmetrical 'football' complex | |||||||||
Components |
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Keywords | CHAPERONE / Human / Mitochondrial / Chaperonin / Complex / Symmetric | |||||||||
Function / homology | Function and homology information coated vesicle / isotype switching to IgG isotypes / mitochondrial unfolded protein response / lipopolysaccharide receptor complex / apolipoprotein A-I binding / TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation / protein import into mitochondrial intermembrane space / migrasome / high-density lipoprotein particle binding / positive regulation of T cell mediated immune response to tumor cell ...coated vesicle / isotype switching to IgG isotypes / mitochondrial unfolded protein response / lipopolysaccharide receptor complex / apolipoprotein A-I binding / TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation / protein import into mitochondrial intermembrane space / migrasome / high-density lipoprotein particle binding / positive regulation of T cell mediated immune response to tumor cell / chaperonin ATPase / Mitochondrial protein import / positive regulation of macrophage activation / cellular response to interleukin-7 / biological process involved in interaction with symbiont / MyD88-dependent toll-like receptor signaling pathway / 'de novo' protein folding / sperm plasma membrane / B cell activation / DNA replication origin binding / B cell proliferation / apoptotic mitochondrial changes / chaperone cofactor-dependent protein refolding / positive regulation of interferon-alpha production / apolipoprotein binding / positive regulation of interleukin-10 production / protein maturation / RHOG GTPase cycle / response to unfolded protein / chaperone-mediated protein complex assembly / protein folding chaperone / clathrin-coated pit / isomerase activity / sperm midpiece / response to cold / positive regulation of interleukin-12 production / T cell activation / secretory granule / lipopolysaccharide binding / ATP-dependent protein folding chaperone / osteoblast differentiation / positive regulation of interleukin-6 production / activation of cysteine-type endopeptidase activity involved in apoptotic process / positive regulation of T cell activation / unfolded protein binding / positive regulation of type II interferon production / p53 binding / protein folding / single-stranded DNA binding / double-stranded RNA binding / protein-folding chaperone binding / protein refolding / mitochondrial inner membrane / protein stabilization / early endosome / mitochondrial matrix / positive regulation of apoptotic process / ubiquitin protein ligase binding / negative regulation of apoptotic process / enzyme binding / cell surface / ATP hydrolysis activity / protein-containing complex / mitochondrion / extracellular space / RNA binding / extracellular exosome / ATP binding / membrane / metal ion binding / plasma membrane / cytosol / cytoplasm Similarity search - Function | |||||||||
Biological species | Homo sapiens (human) | |||||||||
Method | X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / molecular replacement / Resolution: 3.15 Å | |||||||||
Authors | Frolow, F. / Azem, A. / Nisemblat, S. | |||||||||
Funding support | Israel, 2items
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Citation | Journal: Proc.Natl.Acad.Sci.USA / Year: 2015 Title: Crystal structure of the human mitochondrial chaperonin symmetrical football complex. Authors: Nisemblat, S. / Yaniv, O. / Parnas, A. / Frolow, F. / Azem, A. #1: Journal: Acta Crystallogr F Struct Biol Commun / Year: 2014 Title: Crystallization and structure determination of a symmetrical 'football' complex of the mammalian mitochondrial Hsp60-Hsp10 chaperonins. Authors: Nisemblat, S. / Parnas, A. / Yaniv, O. / Azem, A. / Frolow, F. | |||||||||
History |
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-Structure visualization
Structure viewer | Molecule: MolmilJmol/JSmol |
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-Downloads & links
-Download
PDBx/mmCIF format | 4pj1.cif.gz | 1.6 MB | Display | PDBx/mmCIF format |
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PDB format | pdb4pj1.ent.gz | 1.3 MB | Display | PDB format |
PDBx/mmJSON format | 4pj1.json.gz | Tree view | PDBx/mmJSON format | |
Others | Other downloads |
-Validation report
Arichive directory | https://data.pdbj.org/pub/pdb/validation_reports/pj/4pj1 ftp://data.pdbj.org/pub/pdb/validation_reports/pj/4pj1 | HTTPS FTP |
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-Related structure data
Related structure data | 1aonS S: Starting model for refinement |
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Similar structure data |
-Links
-Assembly
Deposited unit |
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Unit cell |
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Noncrystallographic symmetry (NCS) | NCS domain:
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