登録情報 | データベース: PDB / ID: 3kbh |
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タイトル | Crystal structure of NL63 respiratory coronavirus receptor-binding domain complexed with its human receptor |
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要素 | - Angiotensin-converting enzyme 2アンジオテンシン変換酵素2
- Spike glycoproteinスパイクタンパク質
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キーワード | HYDROLASE (加水分解酵素) / beta sandwich / Envelope protein (エンベロープ (ウイルス)) / Fusion protein (融合タンパク質) / Glycoprotein (糖タンパク質) / Host-virus interaction / Membrane (生体膜) / Transmembrane (膜貫通型タンパク質) / Virion (ウイルス) / Virulence / Carboxypeptidase / Cell membrane (細胞膜) / Chloride (塩化物) / Metal-binding / Metalloprotease (金属プロテアーゼ) / Protease (プロテアーゼ) / Secreted (分泌) |
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機能・相同性 | 機能・相同性情報
positive regulation of amino acid transport / アンジオテンシン変換酵素2 / positive regulation of L-proline import across plasma membrane / 加水分解酵素; プロテアーゼ; ペプチド結合加水分解酵素; 金属プロテアーゼ / angiotensin-mediated drinking behavior / tryptophan transport / positive regulation of gap junction assembly / regulation of systemic arterial blood pressure by renin-angiotensin / regulation of vasoconstriction / regulation of cardiac conduction ...positive regulation of amino acid transport / アンジオテンシン変換酵素2 / positive regulation of L-proline import across plasma membrane / 加水分解酵素; プロテアーゼ; ペプチド結合加水分解酵素; 金属プロテアーゼ / angiotensin-mediated drinking behavior / tryptophan transport / positive regulation of gap junction assembly / regulation of systemic arterial blood pressure by renin-angiotensin / regulation of vasoconstriction / regulation of cardiac conduction / peptidyl-dipeptidase activity / angiotensin maturation / maternal process involved in female pregnancy / Metabolism of Angiotensinogen to Angiotensins / metallocarboxypeptidase activity / Attachment and Entry / carboxypeptidase activity / negative regulation of signaling receptor activity / positive regulation of cardiac muscle contraction / regulation of cytokine production / ウイルスのライフサイクル / blood vessel diameter maintenance / brush border membrane / regulation of transmembrane transporter activity / negative regulation of smooth muscle cell proliferation / endocytosis involved in viral entry into host cell / 繊毛 / negative regulation of ERK1 and ERK2 cascade / endocytic vesicle membrane / metallopeptidase activity / positive regulation of reactive oxygen species metabolic process / virus receptor activity / regulation of cell population proliferation / regulation of inflammatory response / endopeptidase activity / Induction of Cell-Cell Fusion / Potential therapeutics for SARS / host cell endoplasmic reticulum-Golgi intermediate compartment membrane / entry receptor-mediated virion attachment to host cell / receptor-mediated endocytosis of virus by host cell / Attachment and Entry / membrane fusion / receptor-mediated virion attachment to host cell / host cell surface receptor binding / symbiont entry into host cell / 脂質ラフト / apical plasma membrane / fusion of virus membrane with host plasma membrane / 小胞体 / fusion of virus membrane with host endosome membrane / エンベロープ (ウイルス) / virion membrane / 細胞膜 / extracellular space / extracellular exosome / zinc ion binding / extracellular region / 生体膜 / identical protein binding / 細胞膜類似検索 - 分子機能 Coronavirus S1 glycoprotein, central receptor binding domain (RBD) / Spike glycoprotein, Alphacoronavirus / Spike glycoprotein S1, coronavirus / Coronavirus spike glycoprotein S1 / Spike glycoprotein S2, coronavirus, C-terminal / Coronavirus spike glycoprotein S2, intravirion / Collectrin-like domain profile. / Collectrin domain / Renal amino acid transporter / Peptidase family M2 domain profile. ...Coronavirus S1 glycoprotein, central receptor binding domain (RBD) / Spike glycoprotein, Alphacoronavirus / Spike glycoprotein S1, coronavirus / Coronavirus spike glycoprotein S1 / Spike glycoprotein S2, coronavirus, C-terminal / Coronavirus spike glycoprotein S2, intravirion / Collectrin-like domain profile. / Collectrin domain / Renal amino acid transporter / Peptidase family M2 domain profile. / Peptidase M2, peptidyl-dipeptidase A / アンジオテンシン変換酵素 / Neutral zinc metallopeptidases, zinc-binding region signature. / Spike glycoprotein S2, coronavirus, heptad repeat 1 / Spike glycoprotein S2, coronavirus, heptad repeat 2 / Coronavirus spike (S) glycoprotein S2 subunit heptad repeat 2 (HR2) region profile. / Coronavirus spike (S) glycoprotein S2 subunit heptad repeat 1 (HR1) region profile. / Spike glycoprotein S2 superfamily, coronavirus / Spike glycoprotein S2, coronavirus / Coronavirus spike glycoprotein S2 / Coronavirus spike glycoprotein S1, C-terminal / Coronavirus spike glycoprotein S1, C-terminal / Immunoglobulin-like / サンドイッチ / Mainly Beta類似検索 - ドメイン・相同性 |
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生物種 | Homo sapiens (ヒト) Human coronavirus NL63 (ヒトコロナウイルスNL63) |
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手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 3.31 Å |
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データ登録者 | Wu, K. / Li, W. / Peng, G. / Li, F. |
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引用 | ジャーナル: Proc.Natl.Acad.Sci.USA / 年: 2009 タイトル: Crystal structure of NL63 respiratory coronavirus receptor-binding domain complexed with its human receptor. 著者: Wu, K. / Li, W. / Peng, G. / Li, F. |
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履歴 | 登録 | 2009年10月20日 | 登録サイト: RCSB / 処理サイト: RCSB |
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改定 1.0 | 2009年12月15日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2011年7月13日 | Group: Advisory / Refinement description / Version format compliance |
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改定 1.2 | 2018年4月18日 | Group: Data collection / カテゴリ: diffrn_detector / Item: _diffrn_detector.detector |
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改定 1.3 | 2020年7月29日 | Group: Advisory / Data collection ...Advisory / Data collection / Derived calculations / Structure summary カテゴリ: chem_comp / database_PDB_caveat ...chem_comp / database_PDB_caveat / entity / pdbx_chem_comp_identifier / pdbx_entity_nonpoly / struct_conn / struct_site / struct_site_gen Item: _chem_comp.name / _chem_comp.type ..._chem_comp.name / _chem_comp.type / _entity.pdbx_description / _pdbx_entity_nonpoly.name / _struct_conn.pdbx_dist_value / _struct_conn.pdbx_leaving_atom_flag / _struct_conn.pdbx_role / _struct_conn.ptnr1_auth_asym_id / _struct_conn.ptnr1_auth_seq_id / _struct_conn.ptnr1_label_asym_id / _struct_conn.ptnr1_label_seq_id / _struct_conn.ptnr2_auth_asym_id / _struct_conn.ptnr2_auth_seq_id / _struct_conn.ptnr2_label_asym_id 解説: Carbohydrate remediation / Provider: repository / タイプ: Remediation |
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