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TitleToward the understanding of DSG2 and CD46 interaction with HAdV-11 fiber, a super-complex analysis.
Journal, issue, pagesJ Virol, Vol. 97, Issue 11, Page e0091023, Year 2023
Publish dateNov 30, 2023
AuthorsGregory Effantin / Marc-André Hograindleur / Daphna Fenel / Pascal Fender / Emilie Vassal-Stermann /
PubMed AbstractThe main limitation of oncolytic vectors is neutralization by blood components, which prevents intratumoral administration to patients. Enadenotucirev, a chimeric HAdV-11p/HAdV-3 adenovirus ...The main limitation of oncolytic vectors is neutralization by blood components, which prevents intratumoral administration to patients. Enadenotucirev, a chimeric HAdV-11p/HAdV-3 adenovirus identified by bio-selection, is a low seroprevalence vector active against a broad range of human carcinoma cell lines. At this stage, there's still some uncertainty about tropism and primary receptor utilization by HAdV-11. However, this information is very important, as it has a direct influence on the effectiveness of HAdV-11-based vectors. The aim of this work is to determine which of the two receptors, DSG2 and CD46, is involved in the attachment of the virus to the host, and what role they play in the early stages of infection.
External linksJ Virol / PubMed:37921471 / PubMed Central
MethodsEM (single particle)
Resolution3.2 - 3.5 Å
Structure data

18453

8qjx

EMDB-18453, PDB-8qjx:
Human Adenovirus type 11 fiber knob in complex with two copies of its cell receptor, Desmoglein-2
Method: EM (single particle) / Resolution: 3.3 Å

18454

8qjy

EMDB-18454, PDB-8qjy:
Human Adenovirus type 11 fiber knob in complex with two copies of its cell receptor, Desmoglein-2
Method: EM (single particle) / Resolution: 3.5 Å

18455

8qk3

EMDB-18455, PDB-8qk3:
Human Adenovirus type 11 fiber knob in complex with its cell receptors, Desmoglein-2 and CD46
Method: EM (single particle) / Resolution: 3.2 Å

Source
  • Escherichia coli (E. coli)
  • homo sapiens (human)
  • human adenovirus 11
KeywordsVIRAL PROTEIN / adenovirus / cell entry / receptor binding

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