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TitleTransferrin receptor binds virus capsid with dynamic motion.
Journal, issue, pagesProc Natl Acad Sci U S A, Vol. 116, Issue 41, Page 20462-20471, Year 2019
Publish dateOct 8, 2019
AuthorsHyunwook Lee / Heather M Callaway / Javier O Cifuente / Carol M Bator / Colin R Parrish / Susan L Hafenstein /
PubMed AbstractCanine parvovirus (CPV) is an important pathogen causing severe diseases in dogs, including acute hemorrhagic enteritis, myocarditis, and cerebellar disease. Cross-species transmission of CPV occurs ...Canine parvovirus (CPV) is an important pathogen causing severe diseases in dogs, including acute hemorrhagic enteritis, myocarditis, and cerebellar disease. Cross-species transmission of CPV occurs as a result of mutations on the viral capsid surface that alter the species-specific binding to the host receptor, transferrin receptor type-1 (TfR). The interaction between CPV and TfR has been extensively studied, and previous analyses have suggested that the CPV-TfR complex is asymmetric. To enhance the understanding of the underlying molecular mechanisms, we determined the CPV-TfR interaction using cryo-electron microscopy to solve the icosahedral (3.0-Å resolution) and asymmetric (5.0-Å resolution) complex structures. Structural analyses revealed conformational variations of the TfR molecules relative to the binding site, which translated into dynamic molecular interactions between CPV and TfR. The precise footprint of the receptor on the virus capsid was identified, along with the identity of the amino acid residues in the virus-receptor interface. Our "rock-and-roll" model provides an explanation for previous findings and gives insights into species jumping and the variation in host ranges associated with new pandemics in dogs.
External linksProc Natl Acad Sci U S A / PubMed:31548398 / PubMed Central
MethodsEM (single particle)
Resolution3.0 - 6.7 Å
Structure data

20001

6oas

EMDB-20001, PDB-6oas:
Structure of canine parvovirus in complex with transferrin receptor type-1
Method: EM (single particle) / Resolution: 3.0 Å

EMDB-20002:
Structure of canine parvovirus in complex with transferrin receptor type-1
Method: EM (single particle) / Resolution: 6.2 Å

EMDB-20003:
Transferrin-transferrin receptor complex bound to canine parvovirus capsid
Method: EM (single particle) / Resolution: 6.7 Å

Source
  • CPV-2 (virus)
  • Canis mesomelas (black-backed jackal)
  • canine parvovirus 2
KeywordsVIRUS / CPV / TfR / icosahedral / cryo

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