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TitleThe C-Terminal Arm of the Human Papillomavirus Major Capsid Protein Is Immunogenic and Involved in Virus-Host Interaction.
Journal, issue, pagesStructure, Vol. 24, Issue 6, Page 874-885, Year 2016
Publish dateJun 7, 2016
AuthorsZhihai Li / Xiaodong Yan / Hai Yu / Daning Wang / Shuo Song / Yunbing Li / Maozhou He / Qiyang Hong / Qingbing Zheng / Qinjian Zhao / Ying Gu / Jun Zhang / Mandy E W Janssen / Giovanni Cardone / Norman H Olson / Timothy S Baker / Shaowei Li / Ningshao Xia /
PubMed AbstractCervical cancer is the second most prevalent malignant tumor among women worldwide. High-risk human papillomaviruses (HPVs) are believed to be the major causative pathogens of mucosal epithelial ...Cervical cancer is the second most prevalent malignant tumor among women worldwide. High-risk human papillomaviruses (HPVs) are believed to be the major causative pathogens of mucosal epithelial cancers including cervical cancer. The HPV capsid is made up of 360 copies of major (L1) and 72 copies of minor (L2) capsid proteins. To date, limited high-resolution structural information about the HPV capsid has hindered attempts to understand details concerning the mechanisms by which HPV assembles and infects cells. In this study, we have constructed a pseudo-atomic model of the HPV59 L1-only capsid and demonstrate that the C-terminal arm of L1 participates in virus-host interactions. Moreover, when conjugated to a scaffold protein, keyhole limpet hemocyanin (KLH), this arm is immunogenic in vivo. These results provide new insights that will help elucidate HPV biology, and hence pave a way for the design of next-generation HPV vaccines.
External linksStructure / PubMed:27276427 / PubMed Central
MethodsEM (single particle) / X-ray diffraction
Resolution4.011 - 6.0 Å
Structure data

8147

5jb1

EMDB-8147: Cryo-EM structure of Human Papillomavirus Type 59 L1 Virus-like Particle
PDB-5jb1: Pseudo-atomic structure of Human Papillomavirus Type 59 L1 Virus-like Particle
Method: EM (single particle) / Resolution: 6.0 Å

PDB-5j6r:
Crystal structure of Human Papillomavirus Type 59 L1 pentamer
Method: X-RAY DIFFRACTION / Resolution: 4.011 Å

Source
  • human papillomavirus type 59
KeywordsVIRAL PROTEIN / Major structural protein / Pentamer / VIRUS / Capsid / T=7 icosahedral / Virus-like Particle

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