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TitleVirological characteristics of the SARS-CoV-2 Omicron BA.2.75 variant.
Journal, issue, pagesCell Host Microbe, Vol. 30, Issue 11, Page 1540-1555.e15, Year 2022
Publish dateNov 9, 2022
AuthorsAkatsuki Saito / Tomokazu Tamura / Jiri Zahradnik / Sayaka Deguchi / Koshiro Tabata / Yuki Anraku / Izumi Kimura / Jumpei Ito / Daichi Yamasoba / Hesham Nasser / Mako Toyoda / Kayoko Nagata / Keiya Uriu / Yusuke Kosugi / Shigeru Fujita / Maya Shofa / Mst Monira Begum / Ryo Shimizu / Yoshitaka Oda / Rigel Suzuki / Hayato Ito / Naganori Nao / Lei Wang / Masumi Tsuda / Kumiko Yoshimatsu / Jin Kuramochi / Shunsuke Kita / Kaori Sasaki-Tabata / Hideo Fukuhara / Katsumi Maenaka / Yuki Yamamoto / Tetsuharu Nagamoto / Hiroyuki Asakura / Mami Nagashima / Kenji Sadamasu / Kazuhisa Yoshimura / Takamasa Ueno / Gideon Schreiber / Akifumi Takaori-Kondo / / Kotaro Shirakawa / Hirofumi Sawa / Takashi Irie / Takao Hashiguchi / Kazuo Takayama / Keita Matsuno / Shinya Tanaka / Terumasa Ikeda / Takasuke Fukuhara / Kei Sato /
PubMed AbstractThe SARS-CoV-2 Omicron BA.2.75 variant emerged in May 2022. BA.2.75 is a BA.2 descendant but is phylogenetically distinct from BA.5, the currently predominant BA.2 descendant. Here, we show that BA.2. ...The SARS-CoV-2 Omicron BA.2.75 variant emerged in May 2022. BA.2.75 is a BA.2 descendant but is phylogenetically distinct from BA.5, the currently predominant BA.2 descendant. Here, we show that BA.2.75 has a greater effective reproduction number and different immunogenicity profile than BA.5. We determined the sensitivity of BA.2.75 to vaccinee and convalescent sera as well as a panel of clinically available antiviral drugs and antibodies. Antiviral drugs largely retained potency, but antibody sensitivity varied depending on several key BA.2.75-specific substitutions. The BA.2.75 spike exhibited a profoundly higher affinity for its human receptor, ACE2. Additionally, the fusogenicity, growth efficiency in human alveolar epithelial cells, and intrinsic pathogenicity in hamsters of BA.2.75 were greater than those of BA.2. Our multilevel investigations suggest that BA.2.75 acquired virological properties independent of BA.5, and the potential risk of BA.2.75 to global health is greater than that of BA.5.
External linksCell Host Microbe / PubMed:36272413 / PubMed Central
MethodsEM (single particle)
Resolution2.86 - 3.48 Å
Structure data

34221

8gs6

EMDB-34221: SARS-CoV-2 BA.2.75 spike glycoprotein (closed state 1)
PDB-8gs6: Structure of the SARS-CoV-2 BA.2.75 spike glycoprotein (closed state 1)
Method: EM (single particle) / Resolution: 2.86 Å

EMDB-34222: SARS-CoV-2 BA.2.75 spike glycoprotein (closed state 2)
Method: EM (single particle) / Resolution: 3.15 Å

EMDB-34223: SARS-CoV-2 BA.2.75 spike glycoprotein (1-up state)
Method: EM (single particle) / Resolution: 2.92 Å

EMDB-34224: SARS-CoV-2 BA.2.75 spike glycoprotein in complex with ACE2
Method: EM (single particle) / Resolution: 3.48 Å

Chemicals

ChemComp-NAG:
2-acetamido-2-deoxy-beta-D-glucopyranose / N-Acetylglucosamine

Source
  • severe acute respiratory syndrome coronavirus 2
  • Homo sapiens (human)
KeywordsVIRAL PROTEIN / spike glycoprotein

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