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TitleCryo-EM structure of the SARS-CoV-2 Omicron spike.
Journal, issue, pagesCell Rep, Vol. 38, Issue 9, Page 110428, Year 2022
Publish dateMar 1, 2022
AuthorsGabriele Cerutti / Yicheng Guo / Lihong Liu / Liyuan Liu / Zhening Zhang / Yang Luo / Yiming Huang / Harris H Wang / David D Ho / Zizhang Sheng / Lawrence Shapiro /
PubMed AbstractThe recently reported B.1.1.529 Omicron variant of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) includes 34 mutations in the spike protein relative to the Wuhan strain, including 15 ...The recently reported B.1.1.529 Omicron variant of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) includes 34 mutations in the spike protein relative to the Wuhan strain, including 15 mutations in the receptor-binding domain (RBD). Functional studies have shown Omicron to substantially escape the activity of many SARS-CoV-2-neutralizing antibodies. Here, we report a 3.1 Å-resolution cryoelectron microscopy (cryo-EM) structure of the Omicron spike protein ectodomain. The structure depicts a spike that is exclusively in the 1-RBD-up conformation with high mobility of RBD. Many mutations cause steric clashes and/or altered interactions at antibody-binding surfaces, whereas others mediate changes of the spike structure in local regions to interfere with antibody recognition. Overall, the structure of the Omicron spike reveals how mutations alter its conformation and explains its extraordinary ability to evade neutralizing antibodies.
External linksCell Rep / PubMed:35172173 / PubMed Central
MethodsEM (single particle)
Resolution3.11 Å
Structure data

25896

7thk

EMDB-25896, PDB-7thk:
Cryo-EM structure of prefusion SARS-CoV-2 spike omicron B.1.1.529 variant
Method: EM (single particle) / Resolution: 3.11 Å

Chemicals

ChemComp-NAG:
2-acetamido-2-deoxy-beta-D-glucopyranose / N-Acetylglucosamine

Source
  • severe acute respiratory syndrome coronavirus 2
KeywordsVIRAL PROTEIN / Fusion protein / Spike glycoprotein / COVID-19 / RBD / NTD

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