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TitleCryo-EM structure of a proton-activated chloride channel TMEM206.
Journal, issue, pagesSci Adv, Vol. 7, Issue 9, Year 2021
Publish dateFeb 24, 2021
AuthorsZengqin Deng / Yonghui Zhao / Jing Feng / Jingying Zhang / Haiyan Zhao / Michael J Rau / James A J Fitzpatrick / Hongzhen Hu / Peng Yuan /
PubMed AbstractTMEM206 has been recently identified as an evolutionarily conserved chloride channel that underlies ubiquitously expressed, proton-activated, outwardly rectifying anion currents. Here, we report the ...TMEM206 has been recently identified as an evolutionarily conserved chloride channel that underlies ubiquitously expressed, proton-activated, outwardly rectifying anion currents. Here, we report the cryo-electron microscopy structure of pufferfish TMEM206, which forms a trimeric channel, with each subunit comprising two transmembrane segments and a large extracellular domain. An ample vestibule in the extracellular region is accessible laterally from the three side portals. The central pore contains multiple constrictions. A conserved lysine residue near the cytoplasmic end of the inner helix forms the presumed chloride ion selectivity filter. Unprecedentedly, the core structure and assembly closely resemble those of the epithelial sodium channel/degenerin family of sodium channels that are unrelated in amino acid sequence and conduct cations instead of anions. Together with electrophysiology, this work provides insights into ion conduction and gating for a new class of chloride channels that is architecturally distinct from previously characterized chloride channel families.
External linksSci Adv / PubMed:33627432 / PubMed Central
MethodsEM (single particle)
Resolution3.46 - 6.17 Å
Structure data

EMDB-22342:
Cryo-EM reconstruction of a proton-activated chloride channel at 6.2 Angstrom resolution
Method: EM (single particle) / Resolution: 6.17 Å

22343

7ji3

EMDB-22343, PDB-7ji3:
Cryo-EM structure of a proton-activated chloride channel
Method: EM (single particle) / Resolution: 3.46 Å

Source
  • Takifugu rubripes (torafugu)
  • takifugu bimaculatus (fish)
KeywordsTRANSPORT PROTEIN / ion channel

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