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-Structure paper
Title | The role of lysine 200 in the human farnesyl pyrophosphate synthase catalytic mechanism and the mode of inhibition by the nitrogen-containing bisphosphonates |
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Journal, issue, pages | TO BE PUBLISHED |
Publish date | Oct 21, 2013 (structure data deposition date) |
Authors | Tsoumpra, M.K. / Muniz, J.R.C. / Barnett, B.L. / Pilka, E. / Kwaasi, A.A. / Kavanagh, K.L. / Evdokimov, A. / Walter, R.L. / Ebetino, F.H. / Oppermann, U. ...Tsoumpra, M.K. / Muniz, J.R.C. / Barnett, B.L. / Pilka, E. / Kwaasi, A.A. / Kavanagh, K.L. / Evdokimov, A. / Walter, R.L. / Ebetino, F.H. / Oppermann, U. / Russell, R.G.G. / Dunford, J.E. |
External links | Search PubMed |
Methods | X-ray diffraction |
Resolution | 2.11 Å |
Structure data | PDB-4n9u: |
Chemicals | ChemComp-MG: ChemComp-RIS: ChemComp-EDO: ChemComp-HOH: |
Source |
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Keywords | TRANSFERASE / alpha-helical prenyltransferase fold / Isoprene Biosynthesis / Lipid Synthesis / Steroid Biosynthesis / Dimethylallyl Pyrophosphate / Isopentenyl Pyrophosphate |