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Title | Structure-Based Design of 2-Arylamino-4-Cyclohexyl Methyl-5-Nitroso-6-Aminopyrimidine Inhibitors of Cyclin-Dependent Kinases 1 and 2 |
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Journal, issue, pages | Bioorg. Med. Chem. Lett., Vol. 13, Page 3079-, Year 2003 |
Publish date | May 13, 2003 (structure data deposition date) |
Authors | Sayle, K.L. / Bentley, J. / Boyle, F.T. / Calvert, A.H. / Cheng, Y. / Curtin, N.J. / Endicott, J.A. / Golding, B.T. / Hardcastle, I.R. / Jewsbury, P. ...Sayle, K.L. / Bentley, J. / Boyle, F.T. / Calvert, A.H. / Cheng, Y. / Curtin, N.J. / Endicott, J.A. / Golding, B.T. / Hardcastle, I.R. / Jewsbury, P. / Mesguiche, V. / Newell, D.R. / Noble, M.E.M. / Parsons, R.J. / Pratt, D.J. / Wang, L.Z. / Griffin, R.J. |
External links | Bioorg. Med. Chem. Lett. / PubMed:12941338 |
Methods | X-ray diffraction |
Resolution | 2.6 Å |
Structure data | PDB-1ogu: |
Chemicals | ChemComp-ST8: ChemComp-SGM: ChemComp-HOH: |
Source |
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Keywords | TRANSFERASE / KINASE / SERINE/THREONINE-PROTEIN KINASE / ATP-BINDING / CELL CYCLE / CELL DIVISION / MITOSIS / PHOSPHORYLATION |